Inhibition of juvenile hormone synthesis in mosquitoes by the methylation inhibitor 3-deazaneplanocin A (DZNep)
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چکیده
منابع مشابه
3-Deazaneplanocin A (DZNep), an Inhibitor of the Histone Methyltransferase EZH2, Induces Apoptosis and Reduces Cell Migration in Chondrosarcoma Cells
OBJECTIVE Growing evidences indicate that the histone methyltransferase EZH2 (enhancer of zeste homolog 2) may be an appropriate therapeutic target in some tumors. Indeed, a high expression of EZH2 is correlated with poor prognosis and metastasis in many cancers. In addition, 3-Deazaneplanocin A (DZNep), an S-adenosyl-L homocysteine hydrolase inhibitor which induces EZH2 protein depletion, lead...
متن کاملPredictive Biomarkers and Personalized Medicine TP53GenomicStatusRegulates Sensitivity of GastricCancer Cells to the HistoneMethylation Inhibitor 3-Deazaneplanocin A (DZNep)
Purpose: DZNep (3-deazaneplanocin A) depletes EZH2, a critical component of polycomb repressive complex 2 (PRC2), which is frequently deregulated in cancer. Despite exhibiting promising anticancer activity, the specific genetic determinants underlying DZNep responsiveness in cancer cells remain largely unknown. We sought to determine molecular factors influencing DZNep response in gastric cance...
متن کاملDZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.
DNA methylation, histone modifications, and nucleosomal occupancy collaborate to cause silencing of tumor-related genes in cancer. The development of drugs that target these processes is therefore important for cancer therapy. Inhibitors of DNA methylation and histone deacetylation have been approved by the Food and Drug Administration for treatment of hematologic malignancies. However, drugs t...
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ژورنال
عنوان ژورنال: Insect Biochemistry and Molecular Biology
سال: 2019
ISSN: 0965-1748
DOI: 10.1016/j.ibmb.2019.103183